Searchable abstracts of presentations at key conferences on reproductive biology and medicine

ra0003p061 | (1) | SRF2016

Altered expression of genes affecting oestrogen metabolism and action in granulosa-lutein cells of women with PCOS

Coates Melanie , Lerner Avigdor , Christopoulos Georgios , Liyanage Maneshka , Lavery Stuart , Tsui Victoria , Hardy Kate , Franks Stephen

Introduction: Polycystic ovary syndrome (PCOS) is a common endocrinopathy in premenopausal women and is associated with hyperandrogenism, anovulatory infertility, and metabolic abnormalities. Abnormalities in the steroidogenic pathway of both theca and granulosa cells have previously been reported, but there has been no comprehensive analysis of steroidogenic gene expression in granulosa-lutein (GL) cells of women with PCOS. In this study, we investigated a panel of genes invo...